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PURPOSE: To report increased eyelid pigmentation as an adverse side effect associated with topical latanoprost. METHOD: Case report: a 62-year-old Korean woman with normal-tension glaucoma developed bilateral increased eyelid skin pigmentation four months after beginning treatment with latanoprost in both eyes. Clinical examinations were performed, and external photographs made. RESULTS: Latanoprost was discontinued. Periodical examinations revealed that the eyelid skin pigmentation gradually diminished one month after the cessation of the drug, and decrease in pigmentation continued over four months of follow-up. CONCLUSIONS: An increase in eyelid skin pigmentation is a possible complication of topical latanoprost therapy, and the cessation of the drug can result in loss of induced pigmentation in humans.
Dr. M.S. Kook, Department of Ophthalmology, Ulsan University School of Medicine, Asan Medical Center, Seoul, South Korea
11.4 Prostaglandins (Part of: 11 Medical treatment)