advertisement
Abstract #6192 Published in IGR 2-2
A comparison of latanoprost and dorzolamide in patients with glaucoma and ocular hypertension: a 3-month, randomised study
O'Donoghue EP; Austin M; Bates K; Birch M; Clearkin L; Condon P; James B; O'Brart D; Phelan P; Robinson RBritish Journal of Ophthalmology 2000; 84: 579-582
AIMS: To compare the effects on intraocular pressure (IOP) and side-effects of monotherapy with either latanoprost or dorzolamide in patients with glaucoma or ocular hypertension. METHODS: Two hundred and twenty-four patients with open-angle glaucoma or ocular hypertension were recruited to a three-month open labelled study. Previous glaucoma medications were washed out and the patients were randomized to receive either latanoprost 0.005% once daily or dorzolamide 2% three times daily. RESULTS: Of the 224 patients, 213 were included in the analysis of efficacy. After three months, latanoprost reduced mean baseline diurnal IOP from 27.2 (SD 3.0) mmHg by 8.5 (3.3) mmHg. The corresponding figures for dorzolamide were 27.2 (3.4) and 5.6 (2.6) mmHg. The difference of 2.9 mmHg (95% CI: 2.3-3.6) was highly significant (p < 0.001, ANCOVA). Latanoprost reduced IOP at peak by 8.6 mmHg (32%) compared with 6.2 mmHg (23%) for dorzolamide, and the difference of 2.4 mmHg was significant (p < 0.001, ANCOVA). The corresponding figures at trough were 8.1 mmHg (31%) for latanoprost and 4.7 mmHg (17%) for dorzolamide, a significant difference of 3.4 mmHg (p < 0.001, ANCOVA). Both drugs were well tolerated systemically and locally. CONCLUSIONS: Latanoprost was superior to dorzolamide in reducing the IOP, judged both from the effect on IOP at peak and trough and by the effect on diurnal IOP.
Dr. E.P. O'Donoghue, Department of Ophthalmology, University College Hospital, Galway, Ireland
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)
