advertisement
Abstract #6210 Published in IGR 2-2
Effects of tetramethylpyrazine on retina of rabbits with experimental glaucoma
Song Z; Cui S; Zhang D; Chen X; Wang YJournal of Xi'an Medical University, English Edition 2000; 12: 23-26+45
OBJECTIVE: To observe the effects of tetramethylpyrazine (TMP) on the retina to find out whether it can protect the retina from glaucomatous damage. METHODS: Twenty-four rabbits were randomly divided into four groups. One eye of each rabbit was model eye induced by 2% methylcellulous, and the other was control eye. Normal saline, TMP, timolol and a combination of timolol and TMP were administered to groups A, B, C and D respectively. At the end of the fourth week, eyes were excavated for light and electron microscopic study. RESULTS: The numbers of ganglion cells (p < 0.01) and bipolar cells (p < 0.01) in model eye were different significantly between groups A and B. In group A, the model eye ganglion cells were karyopyknosis, chromatin margination and nuclear membrane rupture; some inner nuclear cells developed marked lytic changes; outer segment appeared disorganized; but group B changed only slightly. CONCLUSIONS: The results suggest that TMP may protect retina from glaucomatous damage.
Z. Song, Xijing Hospital, Fourth Military Medical University, Xi'an 710032; China
Classification:
11.8 Neuroprotection (Part of: 11 Medical treatment)
