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Abstract #6219 Published in IGR 2-2
No clinically important effects on intraocular pressure after short-term administration of sildenafil citrate (Viagra)
Yajima T; Yajima Y; Koppiker N; Grunwald JE; Laties AMAmerican Journal of Ophthalmology 2000; 129: 675-676
PURPOSE: To assess the short-term effects of sildenafil citrate on intraocular pressure in healthy male volunteers and participants in clinical trials. METHODS: Intraocular pressure and pupil diameter were measured in two placebo-controlled studies. Oral doses of sildenafil citrate (Vuagra; Pfizer Inc, New York, New York) ranged from 10-150 mg. RESULTS: No major changes in intraocular pressure or pupillometry were detected at any time (1.0-24 hours) after administration of sildenafil. Additionally, of 36 subjects with a medical history of increased intraocular pressure in the sildenafil safety database, none were reported to have a clinically significant increase of their intraocular pressure. During clinical trials, two glaucoma cases were listed as serious adverse events, but were not considered treatment related. CONCLUSIONS: No clinical abnormalities were observed in intraocular pressure or pupil diameter in subjects receiving sildenafil. Currently, no evidence suggests that long-term treatment with sildenafil has an effect on intraocular pressure or is associated with the development or worsening of glaucoma.
Dr. T. Yajima, Kaiyo Clinic, Tokyo, Japan
Classification:
11.15 Other drugs in relation to glaucoma (Part of: 11 Medical treatment)
