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Abstract #6228 Published in IGR 2-2
Immediate increase in aqueous humour endothelin 1 concentration and intra-ocular pressure after argon laser trabeculoplasty in the rabbit
Hollo G; Lakatos P; Vargha POphthalmologica 2000; 214: 292-295
PURPOSE: To investigate the immediate changes of aqueous humour endothelin 1 (ET-1) concentration and intraocular pressure (IOP) after argon laser trabeculoplasty (ALT) in the rabbit. METHODS: Standard ALT was performed in one eye of 11 pigmented rabbits. IOP was measured with a Tono-Pen-2 tonometer before treatment, under general anesthesia. Post-laser IOP measurements followed by aqueous humor aspiration were performed under general anesthesia 30 and 60 minutes after treatment in six and five animals, respectively. RESULTS: The aqueous humor ET-1 concentration was significantly higher (55.0 pg/ml) after ALT than in the contralateral eyes without laser treatment (8.2 pg/ml, p = 0.001). IOP increased significantly after ALT (p = 0.007) but remained unaltered (p = 0.10) in the contralateral eyes without treatment. No statistically significant difference was found either in post-laser IOP elevation or in interocular ET-1 difference between the groups. CONCLUSIONS: The results suggest that in the rabbit the increase in aqueous humour ET-1 concentration after ALT is immediate, detectable even 30 minutes after the laser treatment, followed by no further increase during the second 30-minute period after ALT, and associated with an immediate postlaser IOP elevation within one hour after ALT. These findings may suggest a similar response to ALT in the human eye, since a similar immediate IOP elevation is frequently observed after ALT in clinical practice.
Dr. G. Hollo, 1st Department of Ophthalmology, Semmelweis University, Budapest, Hungary
Classification:
12.4 Laser trabeculoplasty and other laser treatment of the angle (Part of: 12 Surgical treatment)
