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Abstract #6282 Published in IGR 2-2
Evaluation of giant-cell deposits on foldable intraocular lenses after combined cataract and glaucoma surgery
Samuelson TW; Chu YR; Kreiger RAJournal of Cataract and Refractive Surgery 2000; 26: 817-823
PURPOSE: To compare the incidence of inflammatory giant-cell deposits (IGCDs) on various foldable intraocular lenses (IOLs) after combined cataract and glaucoma surgery. SETTING: The Phillips Eye Institute, Minneapolis, MN. METHODS: In this prospective randomized clinical trial, 128 patients were randomized to receive a single-piece, first-generation silicone lens (n = 36); a three-piece acrylic lens (n = 40); or three-piece, second-generation silicone lens (n = 52). All patients had combined phacoemulsification and trabeculectomy with mitomycin-C by 1 surgeon using a standardized technique. Dilated biomicroscopy was used to identify and quantitate IGCDs on the surface of the IOLs using a six-point grading scale. RESULTS: Inflammatory giant-cell deposits were identified on 21 of 128 IOLs. Lens design was the most significant risk factor for deposit formation (p = 0.004). Inflammatory giant-cell deposits were most common in the first-generation silicone plate lens group (33%), less common in the acrylic lens group (15%), and least common in the three-piece, second-generation silicone group (5.8%). Density of the deposits was significantly greater on the plate lens than the acrylic or the three-piece silicone lenses (p < 0.0001). Although IOL design was the most significant risk factor for IGCD formation, other significant risk factors included intraoperative pupil stretch (p = 0.02) and preoperative miotic use (p = 0.04). CONCLUSIONS: Inflammatory giant-cell deposit formation was significantly greater on first-generation silicone plate IOLs than on acrylic or second-generation silicone IOLs. The deposits were somewhat more common on acrylic IOLs than on second-generation silicone IOLs. However, this difference was not clinically or statistically significant.
Dr. T.W. Samuelson, Phillips Eye Institute, 710 East 24th Street, Minneapolis, MN 55404-3810, USA
Classification:
12.14.3 Phacoemulsification (Part of: 12 Surgical treatment > 12.14 Combined cataract extraction and glaucoma surgery)
