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Abstract #80490 Published in IGR 20-3

Fluctuations of the Intraocular Pressure in Medically Versus Surgically Treated Glaucoma Patients by a Contact Lens Sensor

Muniesa MJ; Ezpeleta J; Benítez I
American Journal of Ophthalmology 2019; 203: 1-11

See also comment(s) by Luciano QuarantaTony Realini


PURPOSE: To compare fluctuations in intraocular pressure (IOP) in medically vs surgically treated glaucoma patients. DESIGN: Prospective, nonrandomized case series. METHODS: IOP-related fluctuations were measured for 24 hours using a contact lens sensor (CLS). SUBJECTS: We performed monitoring with CLS in 91 eyes of 77 patients; 59 eyes were receiving ocular hypotensive medication and had no previous history of glaucoma surgery (medical group), while 32 eyes with open-angle glaucoma (OAG) had previously undergone glaucoma surgery (surgical group). MAIN OUTCOME MEASURES: The amplitude, expressed as an indicator of the IOP-related fluctuation, and the presence of a nocturnal acrophase. We also identified maximum and minimum IOP-related values for each patient. RESULTS: The mean (standard deviation) amplitude of IOP-related CLS signal in the group of surgically treated eyes was 100 (41) mV eq, while in the medically treated group it was 131 (69) mV eq (difference: P = .010). We found that 42.9% of the surgically treated but only 13.8% of the medically treated glaucoma group exhibited an absence of nocturnal acrophase (difference: P = .011). The maximum and minimum IOP-related values for the medical group were statistically higher than the surgical group (P = .001 and P = .006, respectively). CONCLUSIONS: IOP-related fluctuations were larger in eyes with medically treated glaucoma than in those with surgically treated glaucoma. A significantly larger fraction of the surgical group exhibited an absence of nocturnal acrophase compared to the medically treated group.

Department of Ophthalmology, Arnau de Vilanova University Hospital, Lleida, Catalonia, Spain. Electronic address: mariajesus.muniesa@gmail.com.

Full article

Classification:

6.1.2 Fluctuation, circadian rhythms (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
6.1.1 Devices, techniques (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)



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