Abstract #86494 Published in IGR 21-2

Iris and its relevance to angle closure disease: a review

Soh ZD; Thakur S; Majithia S; Nongpiur ME; Cheng CY
British Journal of Ophthalmology 2020; 0:

Glaucoma is a leading cause of irreversible visual impairment, and primary angle closure glaucoma (PACG) affects Asians disproportionately. Whereas advances in ocular imaging have identified several anatomical risk factors, our ability to predict PACG still requires considerable improvement. The iris plays a crucial role in the pathophysiology of angle closure disease, either through a mechanical or vascular mechanism. Irises of closed-angle eyes inhibit vastly different structural constituents as compared with those of open-angle eyes, thereby effecting variations in biomechanical properties and iris fluid conductivity. The clinical consequences include a smaller change in iris volume on pupil dilation in closed-angle eyes, thereby bringing the iris and trabecular meshwork closer in apposition. In this review, we summarise the potential role of the iris in the pathogenesis of angle closure disease.

Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore.

Full article


9.3.5 Primary angle closure (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
2.8 Iris (Part of: 2 Anatomical structures in glaucoma)

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