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Abstract #8834 Published in IGR 5-1
The effects of latanoprost and brimonidine on blood flow velocity of the retrobulbar vessels: a 3-month clinical trial
Übeyt Inan Ü; Samet Ermis S; Yücel A; Öztürk FActa Ophthalmologica Scandinavica 2003; 81: 155-160
OBJECTIVE: To investigate the effects of topical latanoprost 0.005% and topical brimonidine tartrate 0.2% on retrobulbar blood flow in patients with primary open-angle glaucoma (POAG) and ocular hypertension (OHT). METHODS: Forty-one consecutive patients with POAG and OHT were enrolled in this prospective, open-label, randomized, parallel study. Patients received either latanoprost 0.005% or brimonidine 0.2% for three months. Baseline retrobulbar blood flow measurements of the ophthalmic artery, central retinal artery, and temporal short posterior ciliary artery were taken using color Doppler imaging ultrasound, concurrently with systemic blood pressure, heart rate, ocular perfusion pressure, and intraocular pressure (IOP) measurements. These measurements were repeated after three months. RESULTS: Both latanoprost and brimonidine significantly reduced IOP (p < 0.05). While there was a statistically significant increase in peak systolic velocity of the ophthalmic artery, no significant change was observed in the other vessels with latanoprost treatment (p < 0.05). Topical brimonidine did not significantly alter flow velocities or resistive indices in the retrobulbar vessels after three months. CONCLUSION: Topical latanoprost and brimonidine significantly reduced IOP in patients with POAG and OHT without causing significant hemodynamic alterations in the retrobulbar vessels.
Dr. Ü. Übeyt Inan, Department of Ophthalmology, Kocatepe University, School of Medicine, Afyon, Turkey
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
11.3.3 Apraclonidine, brimonidine (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
11.4 Prostaglandins (Part of: 11 Medical treatment)
