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WGC-2021

Abstract #90572 Published in IGR 21-3

Referenced scans improve the repeatability of optical coherence tomography angiography measurements in normal and glaucoma eyes

Rao HL; Dasari S; Riyazuddin M; Lavanya R; P NK; Pradhan ZS; Moghimi S; Mansouri K; Webers CAB; Weinreb RN
British Journal of Ophthalmology 2020; 0:


AIM: To compare the repeatability of peripapillary perfusion density and flux index measurements on referenced and non-referenced optical microangiography (OMAG) scans in normal, glaucoma suspect and glaucoma eyes. METHODS: In a cross-sectional study, 48 eyes (33 subjects) underwent three repeat, non-referenced peripapillary OMAG scans in the same session and 43 eyes (25 subjects) underwent three referenced peripapillary OMAG scans. In the referenced scan group, repeat scans (second and the third scan) were acquired exactly on the baseline (first) scan using the 'track to prior scan' option on the device. Repeatability estimates of the mean and four-sector (temporal, superior, nasal and inferior) OMAG measurements on the non-referenced and referenced scans were assessed using within-subject coefficient of repeatability (CR) and variation (CV). RESULTS: CR (%) of peripapillary perfusion density measurements (range: 2.0-4.1) on non-referenced scans were significantly higher than that on referenced scans (range: 1.4-2.7). CV (%) on non-referenced and referenced scans ranged from 1.7 to 3.1 and from 1.2 to 2.1, respectively . CR of flux index on non-referenced and referenced scans ranged from 4.4 to 5.8 and from 3.6 to 4.8, respectively. CV on non-referenced and referenced scans ranged from 4.1 to 5.2 and from 3.3 to 4.5, respectively. CONCLUSIONS: Repeatability estimates of OMAG measurements were better on referenced scans compared with non-referenced scans. Perfusion density measurements had lower variability than flux index. OCTA-measured perfusion density of referenced scans is preferable for monitoring vascular change in glaucoma.

Narayana Nethralaya, Bangalore, India harshalaxmanarao@gmail.com.

Full article

Classification:

6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)



Issue 21-3

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WGC-2021