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Abstract #9183 Published in IGR 5-2
Effects of 0.005% Latanoprost on Ocular Anterior Structures and Ciliary Body Thickness
Marchini G; Ghilotti G; Bonadimani M; Babighian SJournal of Glaucoma 2003; 12: 295-300
PURPOSE: To assess the effects of 0.005% latanoprost on the anterior segment geometry and ciliary body thickness using ultrasound biomicroscopy. Intraocular pressure (IOP), refraction, visual acuity, and pupil size were also evaluated. PATIENTS AND METHODS: Thirty patients with untreated ocular hypertension or primary open-angle glaucoma (mean age: 59.3 ± 9.9 years) were recruited into this prospective, controlled, open trial. Before and after one week of 0.005% latanoprost administration, the following parameters were tested: refraction, visual acuity, pupil diameter, IOP, five conventional ultrasonographic A-scan variables, 16 ultrasound biomicroscopy parameters, and the ultrasound biomicroscopy ciliary body thicknesses at a distance of 1500 μm (CBT1), 2000 μm (CBT2), and 2500 μm (CBT3) from the scleral spur. RESULTS: Latanoprost 0.005% caused a marked IOP-lowering effect in all patients (from 22.8 ± 3.1 to 14.1 ± 2.9 mmHg; -38%, p < 0.0001), without any refractive, visual acuity, or pupillary alterations. The A-scan echobiometry variables were unchanged, while ultrasound biomicroscopy confirmed a significant post-treatment increase of CBT2 (from 434 ± 140 to 536 ± 127 μm; +102 μm, p = 0.01) and CBT3 (from 319 ± 103 to 412 ± 100 μm; +93 μm, p = 0.003) compared to controls (CBT2: from 493 ± 165 to 473 ± 135 μm; -20 μm, p = NS; CBT3: from 388 ± 130 to 365 ± 87 μm; -23 μm, p = NS). None of the changes observed in the other UBM parameters was statistically significant. No significant correlation was detected between ciliary body thickness increase and IOP-lowering effect. CONCLUSIONS: The increase of ciliary body thickness, which was measured in vivo by ultrasound biomicroscopy and associated with the IOP-lowering effect, indirectly supports the mechanism of uveoscleral outflow enhancement induced by latanoprost. These data are in agreement with the biochemical hypothesis of the passage of the aqueous flow through the extracellular spaces of the ciliary muscle.
Dr. G. Marchini, Clinica Oculistica dell'Università, Ospedale di Borgo Trento, I-37126, Verona, Italy. giorgio.marchini@univr.it
Classification:
6.12 Ultrasonography and ultrasound biomicroscopy (Part of: 6 Clinical examination methods)
11.4 Prostaglandins (Part of: 11 Medical treatment)
