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Abstract #98937 Published in IGR 22-4

Optic Disc Hemorrhage Is Not Associated with Global Choroidal Vessel Loss, but Is Associated with Localized Choroidal Vessel Loss in Glaucoma

Lee A; Shin JW; Lee JY; Baek MS; Kook MS
Journal of clinical medicine 2022; 11:

PURPOSE: To investigate the relationship between optic disc hemorrhage (ODH) and the geographic pattern (regional vs. global) of parapapillary choroidal vessel density (pCVD) loss within the β-parapapillary atrophy (β-PPA) in open-angle glaucoma (OAG) METHODS: This retrospective cross-sectional study included 100 OAG eyes with visual field (VF) defects confined to a single hemifield (50 with and 50 without ODH, matched for age (≤10 years) and VF severity (≤1 decibel) at the same hemifield), as well as 50 healthy eyes. The pCVD was measured using optical coherence tomography angiography (OCTA). The relationships between pCVD and clinical factors were assessed globally and regionally. Logistic regression analyses were performed to determine the clinical factors associated with the presence of ODH. RESULTS: The pCVD values within ODH-affected hemiretinae of ODH+ eyes were significantly lower than those in the matched hemiretinae of ODH- eyes ( = 0.001). The presence of ODH was significantly correlated with a lower pCVD within ODH-dominant inferior hemiretinae ( < 0.05). Lower pCVD values at ODH-affected hemiretinae was significantly associated with the presence of ODH ( < 0.05). CONCLUSIONS: OAG eyes with ODH demonstrate a greater severity of regional pCVD loss at the hemiretinae spatially corresponding to the ODH location compared to OAG eyes without ODH.

Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul 05505, Korea.

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