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Abstract #27271 Published in IGR 12-4
Efficacy and tolerability of one-site versus two-site phacotrabeculectomy: A meta-analysis of randomized controlled clinical trials
Liu H-N; Chen X-L; Li X; Nie Q-Z; Zhu YChinese Medical Journal 2010; 123: 2111-2115
Background: Phacotrabeculectomy can be performed using one-site or two-site incisions. This meta-analysis evaluated the efficacy and tolerability of one-site versus two-site phacotrabeculectomy in the treatment of patients with coexisting cataract and glaucoma. Methods: A comprehensive literature search was performed according to the Cochrane Collaboration methodology to identify randomized controlled clinical trials comparing one-site with two-site phacotrabeculectomy. Studies meeting our predefined criteria were included in the meta-analysis. Efficacy estimates were measured by weighted mean difference (WMD) for the percentage intraocular pressure (IOP) reduction from baseline to end point, relative risk (RR) for the proportion of patients with a best-corrected visual acuity (BCVA) of 0.5 or better after surgery and complete success rates. Tolerability estimates were measured by RR for adverse events. All of outcomes were reported with 95% confidence interval (95% CI). Data were synthesised by Stata 10.1 for Windows. Results: Two-site phacotrabeculectomy was associated with greater reductions in IOP than the one-site procedure (WMD: -5.99, 95% CI: -10.74--1.24, P=0.01). A greater proportion of patients also achieved a BCVA of 0.5 or better (RR: 0.91, 95% CI: 0.74-1.12, P=0.36) and the target IOP without anti-glaucoma medication at the study end point (RR: 0.94, 95% CI: 0.83-1.07, P=0.34) after two-site than one-site phacotrabeculectomy, but the differences were not significant. There were no significant differences in adverse events between two surgical procedures. Conclusions: Two-site phacotrabeculectomy is superior to one-site phacotrabeculectomy in reducing IOP, but other post-operative effects are similar. One-site and two-site phacotrabeculectomies have similar adverse event rates.
X.-L. Chen. Department of Ophthalmology, Shengjing Hospital, China Medical University, Shenyang, Liaoning 110004, China. chenxl@sj-hospital.org
Classification:
12.14.3 Phacoemulsification (Part of: 12 Surgical treatment > 12.14 Combined cataract extraction and glaucoma surgery)