Abstract #52599 Published in IGR 15-1

Switching prostaglandin analogues and 24-hour iop fluctuations

Gil-Carrasco F; Turati-Acosta M; Albis-Donado O; Bello-López-Portillo H; Sánchez-Noguera C; Soto-Ortiz K
Archivos de la Sociedad Espaņola de Oftalmologia 2013; 88: 130-133

OBJECTIVES: To evaluate the fluctuations in 24h mean intraocular pressure (IOP) when switching prostaglandin analogues in patients with glaucoma. METHODS: Fourteen patients with primary open angle glaucoma were evaluated with monthly 24-hour IOP curves, using a monthly switching pattern of prostaglandin analogues and brinzolamide during 3 years of follow-up. RESULTS: Average IOP and average fluctuation (peak to through difference) were significantly higher with brinzolamide than with any of the analogues. There was no significant difference in either parameter with the different prostaglandin analogues, regardless of the order in which they were evaluated, or even if a month on brinzolamide was intercalated between the analogues. CONCLUSIONS: Brinzolamide was less effective than prostaglandin analogues in reducing 24-hour mean IOP and its fluctuations. Switching analogues had no significant effect on mean IOP or mean IOP fluctuations.

Departamento de Glaucoma, Asociación para evitar la ceguera en México, Hospital Dr. Luis Sánchez Bulnes, México, Distrito Federal, México. Electronic address:

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6.1.2 Fluctuation, circadian rhythms (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
12.4 Laser trabeculoplasty and other laser treatment of the angle (Part of: 12 Surgical treatment)

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