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Abstract #15709 Published in IGR 2-3
Optic disc topography after medical treatment to reduce intraocular pressure
Bowd C; Weinreb RN; Lee B; Emdadi A; Zangwill LMAmerican Journal of Ophthalmology 2000; 130: 280-286
PURPOSE: The authors examined changes in optic disc topography using confocal scanning laser ophthalmoscopy after reducing intraocular pressure with administration of latanoprost. METHODS: Twenty-nine patients with glaucoma or ocular hypertension were imaged using the Heidelberg Retina Tomograph before and after the administration of latanoprost to decrease intraocular pressure. Average time between pretreatment and posttreatment imaging was 2.7 ± 1.8 weeks. Heidelberg Retina Tomograph software-measured parameters were mean height of contour, cup area, cup volume, mean cup depth, maximum cup depth, cup shape, rim area, rim volume, cup-to-disc ratio, and retinal nerve fiber thickness. RESULTS: Average intraocular pressure decreased significantly (mean ± SD) by 7.2 ± 5.4 mmHg (25 ± 16% decrease). No statistically significant changes in measured topographic parameters were found. When data from patients with decreases in intraocular pressure of 7 mmHg or greater were analyzed separately (mean intraocular pressure decrease = 10.79 ± 4.32 mmHg, 36 ± 8% decrease), cup area (p = 0.005), cup volume (p = 0.002), and cup-to-disc ratio (p = 0.005) decreased significantly, and rim area (p = 0.005) increased significantly. Linear regression analysis of the data from all subjects showed that a change in intraocular pressure after latanoprost administration accounted for 12% or more of the variance in two measured topographic parameters (mean cup depth and cup shape). CONCLUSIONS: These results suggest that, in some patients, moderate decreases in intraocular pressure may affect disc topography, as measured by the Heidelberg Retina Tomograph. Intraocular pressure should be considered when analyzing consecutive confocal scanning laser ophthalmoscopy images for glaucomatous progression.
Dr. L.M. Zangwill, Glaucoma Center, Diagnostic Imaging Laboratory Diego, University of California, San Diego, CA 92093-0946, USA
Classification:
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
6.9.1 Laser scanning (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)
11.4 Prostaglandins (Part of: 11 Medical treatment)
