Abstract #81323 Published in IGR 20-3

Systemic Determinants of Peripapillary Vessel Density in Healthy African Americans: the African American Eye Disease Study

Chang R; Nelson AJ; LeTran V; Vu B; Burkemper B; Chu Z; Fard A; Kashani AH; Xu BY; Wang RK; Varma R; Richter GM;
American Journal of Ophthalmology 2019; 207: 240-247

See also comment(s) by Zia Pradhan & Harsha Rao

PURPOSE: To determine the relationship between systemic factors and radial peripapillary capillary (RPC) vessel density (VD) in healthy African American (AA) participants of the African American Eye Disease Study. DESIGN: A population-based, cross-sectional study. METHODS: 4135 eyes from 2127 AA participants aged 40 years and older in Inglewood, California, were imaged for 6x6mm optic disc scans on a spectral-domain optical coherence tomography angiography (OCTA) device. Of these, 1029 eyes from 1029 participants who met the inclusion and exclusion criteria were analyzed, including only one eye per participant. Custom software was used to quantify RPC VD. Multivariate linear regression was used to identify systemic factors associated with RPC VD with a significance level set at 0.05. The contribution of each variable to the final model was estimated with the magnitude of standardized regression coefficients (SRC). The fit of the final model was measured by the R. RESULTS: Average RPC VD was 0.346±0.045. Controlling for signal strength, the systemic variables in the final multivariate model associated with reduced RPC VD were older age (β=-0.0123 per decade; SRC=-0.2733; p=<0.0001), male sex (β=-0.0067; SRC=-0.0716; p=0.0060), and longer diabetes duration (β=-0.0022 per 5 years; SRC=-0.0527; p=0.0427). The model R was 0.3689. CONCLUSIONS: Age, sex, and systemic influences, such as diabetes duration, need to be considered when assessing changes in RPC VD in glaucoma and other ocular diseases. Longitudinal studies are needed to investigate whether reduced RPC VD and the factors that affect it are associated with an increased risk of developing glaucomatous nerve damage.

USC Roski Eye Institute, Keck Medicine of University of Southern California, 1450 San Pablo St, Suite 4700, Los Angeles, CA 90033, United States.

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Classification: Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)

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