It has been previously reported that increased oxidative stress plays a role in the development of cataract and the elevation of intraocular pressure in pseudoexfoliation syndrome (PEX) and pseudoexfoliative glaucoma (PXG). Recently, several studies have also suggested that oxidative stress may be increased systemically in PEX/PXG patients. Ozgonul et al. compared the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) between 34 PEX and 29 PXG patients and 42 age and sex-matched healthy control subjects. They found NLR to be significantly increased in PEX and PXG, and PLR to be significantly increased in PXG compared to controls. The authors concluded that their findings provide evidence for an association between NLR and PEX/ PXG, indicating that inflammation plays a role in PEX/PXG. However, their conclusion is not sufficiently supported by data: the study was retrospective and the patients/groups were not controlled for systemic diseases that are known to significantly increase NLR and PRL (e.g., cardiovascular disease, diabetes and malignancies). Therefore this study can only be considered as one of several small reports which address certain aspects of systemic stress in PEX/PXG, but cannot demonstrate a clear association due to methodological problems.