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Top-Five of the 25th American Glaucoma Society Meeting
Fort Lauderdale, Florida, USA, March 3–6, 2016

Christopher A. Girkin and Steven J. Gedde

1. An Ab-Interno Gelatin Stent for the Treatment of Primary Open-Angle Glaucoma: Three- Year Follow-up
   A prospective, multicenter study investigated ab-interno implantation of a transscleral gelatin stent (Xen implant) for patients with medically uncontrolled primary open-angle glaucoma. Mean IOP decreased from 22.7 mmHg to 13.5 mmHg at 36 months, and the mean number of ocular hypotensive medications was reduced from 2.8 medications to 0.8 medication. (Rohit Varma, Los Angeles, CA, USA)
2. A Novel Bayesian Retinal Nerve Fiber Layer Thickness Deviation Map Improves Glaucoma Diagnosis
   A prospective cross-sectional study evaluated a novel Bayesian deviation map, which uses information from both healthy and glaucomatous eyes to generate topographic maps and estimate the probability that a specific location shows RNFL damage. The Bayesian deviation map trained on both glaucoma and healthy eyes had a ROC curve area of 0.95, which was significantly higher than those of average peripapillary RNFL thickness and the standard deviation map (p < 0.05 for all comparisons). (Felipe A. Medeiros, La Jolla, CA, USA)
3. Postoperative Complications in the Ahmed Baerveldt Comparison Study during Five Years of Follow-up
   The Ahmed Baerveldt Comparison (ABC) Study is a multicenter randomized clinical trial comparing the safety and efficacy of the Ahmed glaucoma valve and Baerveldt glaucoma implant. The cumulative rates of late complications were similar after placement of an Ahmed valve (46.8%) and Baerveldt implant (56.3%) during five years of follow-up (p = 0.082). Serious complications associated with vision loss or reoperation developed more frequently after Baerveldt implantation (24.7%) than Ahmed implantation (15.9%) (p = 0.037). (Donald L. Budenz, Chapel Hill, NC, USA)
4. A Comparison of Outcomes of Laser Trabeculoplasty Surgery Performed by Optometrists versus Ophthalmologists in the State of Oklahoma
   Health care claims data were used to compare the outcomes of laser trabeculoplasty performed by optometrists and ophthalmologists in Oklahoma. The proportion of eyes requiring subsequent laser trabeculoplasty was significantly higher when the initial treatment was done by an optometrist (35.0%) rather than an ophthalmologist (14.9%) (p < 0.0001). (Joshua D. Stein, Ann Arbor, MI, USA)
5. PhS-OCT Imaging of Synchronous Trabecular Meshwork and Collector Channel Entrance Motion in Vivo in Human Subjects
   A laboratory prototype spectral domain, phase-sensitive OCT system was used to image and quantitate pulse-dependent aqueous system outflow system motion in five human subjects. A new algorithm was used to remove background in-vivo tissue motion and enhance motion detection of the trabecular meshwork and collector channel entrance providing high-resolution images. (Murray J. Johnstone, Seattle, WA, USA)