News Flashes IGR 19-1

Palmitoylethanolamide, a natural substance in the brain, has known anti-inflammatory actions

Upregulation of IL6 gene in the fibrotic cell lines and a downregulation of PRG4

Pathophysiology of eye aging is not well understood

The clinical and pathologic relationship between AD and glaucoma remains obscure

Patient-obtained IOP measurements were reproducible and similar to physician-obtained ones.

While many trials have examined risk factors for glaucoma and the clinical course of glaucoma suspects in the adult population, similar knowledge specific to the pediatric population is sparse

The current report agrees with other studies in not finding an independent association between macular choroidal thinning and glaucoma risk factors and/or glaucomatous loss

Pseudoexofoliation syndrome may be associated with accelerated aging of the ocular tissues, which may lead to a thinner choroid independent of the duration of the disease

Matrix metalloproteinases are zinc-containing enzymes and play a possible role in glaucoma pathogenesis.

As with other cross sectional studies, it cannot be concluded that zinc or iron levels are a cause or consequence of glaucoma

The results of this study represent the first data on safety and efficacy of a PG analogue (namely travoprost 0.004%) from a double blind prospectively planned randomized clinical trial in pediatric patients

What most patient see is not reflected in the gray scale print out from visual field machines or in online depictions of what glaucoma looks like

While most studies reported good diagnostic value of peripapillary vessel density in glaucoma,the same for macular vessel density was poor

The clinical usefulness of imaging the macular vasculature in glaucoma is likely to be limited since the geriatric macula is affected by several other diseases (age-related macular degeneration, diabetic retinopathy, etc).

Together these results suggest that MSCs are likely producing other soluble neuroprotective factors, in addition to PDGF

Detecting and monitoring glaucoma compared to standard measures such as retinal nerve fiber layer thickness (RNFLT) is less clear

The question remains whether the visualization and quantitation of retinal vasculature will provide additional information that will change glaucoma clinical decision making when RNFL thickness and ganglion cell layer measurements are already available to the clinician

There is a possibility that the lesser RAPD in the NTG group was at least partially affected by the inter-group disease-severity and structural-damage differences between both eyes

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