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Abstract #106244 Published in IGR 23-3
Autologous Serum Eye Drops in the Management of Limbal Stem Cell Deficiency Associated With Glaucoma Surgery
Niruthisard D; Bonnet C; Tanasugarn L; Le B; Deng SXEye Contact Lens 2023; 49: 19-24
PURPOSE: To evaluate safety and efficacy of autologous serum eye drops (AS) in the treatment of limbal stem cell deficiency (LSCD) associated with glaucoma surgery. METHODS: Retrospective case series of eyes with glaucoma surgery-induced LSCD treated with AS. Diagnosis of LSCD was confirmed by anterior segment optical coherence tomography, in vivo confocal microscopy, and/or impression cytology. Limbal stem cell deficiency severity was staged using a clinical scoring system (2-10 points). Outcome measures were changes (≥2 points) of the LSCD score and best-corrected visual acuity (BCVA) from the baseline to the last follow-up. RESULTS: Thirteen eyes of 12 consecutive patients treated with 50% AS for at least 3 months were included. The mean age was 78.9±7.5 years and the mean duration of AS use was 20.9±16.8 months. Indications of AS included LSCD progression in eight eyes (61.5%) and visual axis threatening in five eyes (38.5%). The mean LSCD score at baseline (6.7±1.6) was similar to that at last follow-up (6.5±2.2, P =0.625). Two eyes (15.4%) showed improvement, nine eyes (69.2%) were stable, and two eyes (15.4%) worsened. The mean baseline BCVA (0.89±0.64 logMAR) was similar to the mean final BCVA (1.05±0.63 logMAR, P =0.173). There were no serious adverse complications related to AS. CONCLUSION: AS appears to be well tolerated and may stabilize the progression of LSCD with limited effects. A larger study is necessary to confirm the findings.
Stein Eye Institute (D.N., C.B., B.L., S.X.D.), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Ophthalmology (D.N.), Banphaeo General Hospital, Samut Sakhon, Thailand; Cornea Department (C.B.), Cochin Hospital, AP-HP, Paris University, Paris, France; Department of Tropical Hygiene (L.T.), Faculty of Tropical Medicine, Mahidol University, Thailand; Drexel University College of Medicine (B.L.)Molecular Biology Institute (S.X.D.), University of California, Los Angeles.
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