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Abstract #106622 Published in IGR 23-3
Efficacy of the PRESERFLO MicroShunt and a Meta-Analysis of the Literature
Pawiroredjo SSM; Bramer WM; Pawiroredjo ND; Pals J; Poelman HJ; de Vries VA; Wolfs RCW; Ramdas WDJournal of clinical medicine 2022; 11:
BACKGROUND: Recent studies on the PRESERFLO MicroShunt suggest that it may be effective in lowering intraocular pressure (IOP); however, the number of studies on this device remains limited. Therefore, we assessed the efficacy of the PRESERFLO MicroShunt in patients with glaucoma and performed a meta-analysis of published results. METHODS: Prospective study including all patients that underwent PRESERFLO MicroShunt surgery from 2018 onwards. Sub-analyses were performed for cataract-combined procedures. To compare our results, we performed a systematic review and meta-analysis. IOP, IOP-lowering medication and surgical complications reported in the retrieved studies were assessed. RESULTS: A total of 72 eyes underwent PRESERFLO-implant surgery (59 as standalone procedure and 13 as cataract-combined procedure). No significant differences were found in IOP and IOP-lowering medication between both groups. The mean ± standard deviation IOP and IOP-lowering medications of both groups taken together declined from 21.72 ± 8.35 to 15.92 ± 8.54 mmHg ( < 0.001, 26.7% reduction) and 3.40 to 0.93 ( < 0.001, 72.6% reduction) at 1 year follow-up, respectively. Secondary surgeries were required in 19.4% of eyes, the majority (71.4%) within 6 months. The meta-analysis including 14 studies (totaling 1213 PRESERFLO MicroShunt surgeries) from the systematic review showed a mean preoperative IOP and IOP-lowering medication of 22.28 ± 5.38 and 2.97 ± 1.07, respectively. The three-years postoperative pooled mean was (weighted mean difference, 95% CI) 11.07 (10.27 [8.23-12.32], < 0.001) mmHg and 0.91 (1.77 [1.26-2.28], < 0.001) for IOP and IOP-lowering medication, respectively. The most common reported complication was hypotony (2-39%). CONCLUSION: The PRESERFLO MicroShunt is effective and safe in lowering IOP and the number of IOP-lowering medications.
Department of Ophthalmology, Erasmus Medical Center, University Medical Center, 3000 CA Rotterdam, The Netherlands.
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