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Abstract #112346 Published in IGR 24-3
Glaucoma-associated abnormalities in cortical activity during a visuocognitive task
Garric C; Wamain Y; Rouland JF; Lenoble QClinical Neurophysiology 2023; 156: 47-56
OBJECTIVE: To investigate neurophysiological dynamics during a visuocognitive task in glaucoma patients vs. healthy controls. METHODS: Fifteen patients with early-stage primary open-angle glaucoma (POAG) and fifteen age-matched healthy participants underwent a "go/no-go" task, monitored with EEG. Participants had to semantically categorize visual objects in central vision, with animal or furniture as targets according to the experimental block. RESULTS: Early visual processing was delayed by 50 ms in patients with POAG compared to controls. The patients displayed a smaller difference between animal and furniture categorization during higher-level cognitive processing (at 400-600 ms). Regarding behavioral data, the groups differed in accuracy performance and decision criterion. As opposed to the control group, patients did not display facilitation and a higher accuracy rate for animal stimuli. However, patients maintained a consistent decision criterion throughout the experiment, whereas controls displayed a shift towards worse decision criteria in furniture trials, with higher error rate. CONCLUSIONS: The comparative analysis of behavioral and neurophysiological data revealed in POAG patients a delay in early visual processing, and potential high-level cognitive compensation during late, task-dependent activations. SIGNIFICANCE: To our knowledge, our findings provide the first evidence of modification in cognitive brain dynamics associated with POAG.
Univ. Lille, INSERM, CHU Lille, U1172 - LilNCog - Lille Neuroscience and Cognition, F-59000 Lille, France. Electronic address: clementine.garric@u-paris.fr.
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