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Abstract #14625 Published in IGR 8-4
Neuroprotective properties of erythropoietin on neuro-retinopathy
Li D; Duan X-CInternational Journal of Ophthalmology 2006; 6: 860-864
Erythropoietin (EPO) is a hematopoietic growth factor and cytokine which stimulates erythropoiesis. In recent years, Epo has been shown to have important nonhematopoietic functions in the nervous system. A wide variety of experimental studies have shown that EPO and its receptor (EPOR) are expressed in the nervous system and EPO exerts remarkable neuroprotection in cell culture and animal models of nervous system disorders. The apoptosis of retinal ganglion cell (RGC) and photoceptor cell are common causes of reduced visual function in several ocular diseases, including glaucoma, retinal detachment, retinal pigmental degeneration, etc. EPO may be a potent neuroprotective therapeutic agent for the treatment of ocular disease that are characterized by RGC and photoceptor cell death. In this review, we summarized the current knowledge on the neurotrophic and neuroprotective properties of EPO, the mechanisms by which EPO produces neuroprotection and the signal transduction systems regulated by EPO in the nervous system, which may represent the potential basis for future strategies against neuronal injury. LA: Chinese
Dr. X.-C. Duan, Department of Ophthalmology, Second Xiangya Hospital, Central-South University, Changsha 410011 Hunan Province, China
Classification:
3.9 Pathophysiology (Part of: 3 Laboratory methods)
11.8 Neuroprotection (Part of: 11 Medical treatment)
