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Abstract #58916 Published in IGR 16-3
Effect of the Aβ aggregation modulator MRZ-99030 on retinal damage in an animal model of glaucoma
Salt TE; Nizari S; Cordeiro MF; Russ H; Danysz WNeurotoxicity research 2014; 26: 440-446
Several lines of evidence suggest that there are similarities in the pathomechanisms of glaucoma and Alzheimer's disease, and that amyloid-beta (Aβ) could be a new, promising target for neuroprotective therapy of glaucoma. In the present study, we evaluated the effect of the Aβ aggregation modulator MRZ-99030 in the Morrison model of glaucoma based on increased intraocular pressure (IOP) in rats. MRZ-99030 provided dose-dependent neuroprotection and at the highest dose (240 mg/kg) reduced the degree of RGC apoptosis to 33 % of that seen after vehicle (P < 0.05; one-way ANOVA). No significant effect on IOP was observed. Pharmacokinetic experiments showed that following systemic injection of MRZ-99030, concentrations above affinity for Aβ were reached. Hence the present results are consistent with the notion that Aβ is a promising target for neuroprotective intervention in glaucoma and that MRZ-99030 may be a good drug candidate for further development.
Visual Neuroscience, UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK.
Full articleClassification:
5.1 Rodent (Part of: 5 Experimental glaucoma; animal models)
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
11.8 Neuroprotection (Part of: 11 Medical treatment)
