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Abstract #59605 Published in IGR 16-3
Macular Ganglion Cell Imaging Study: Interocular Symmetry of Ganglion Cell-Inner Plexiform Layer Thickness in Normal Healthy Eyes
Lee SY; Jeoung JW; Park KH; Kim DMAmerican Journal of Ophthalmology 2015; 159: 315-23.e2
PURPOSE: To determine cutoffs for interocular differences in ganglion cell-inner plexiform layer thickness in normal healthy eyes and to evaluate the diagnostic performance of these values for differentiating between normal subjects and glaucoma patients. DESIGN: Observational, cross-sectional study METHODS: Macular and optic disc scanning were performed in 275 normal subjects, 58 glaucoma patients, and 58 normal controls by Cirrus high-definition optical coherence tomography. The ganglion cell-inner plexiform layer thickness was calculated, and the normal ranges of the interocular differences were determined as 2.5 and 97.5 percentiles. The signed and absolute interocular differences were compared between normal subjects and glaucoma patients. RESULTS: The mean ± standard deviation interocular difference in the average ganglion cell-inner plexiform layer thickness thickness was 0.10 ± 2.31 μm, which was not statistically significant (P = 0.466). The 2.5 and 97.5 percentiles of the interocular difference were -4.10 μm and +5.00 μm, respectively. On multiple regression analysis, the interocular difference in axial length was correlated with the interocular difference in average ganglion cell-inner plexiform layer thickness thickness (β = 2.044, P = 0.003). The signed and absolute interocular differences in ganglion cell-inner plexiform layer thickness were higher in glaucoma patients than in normal subjects (all P < 0.001). Sensitivity and specificity of absolute interocular differences ranged from 25.9% to 51.7% and from 93.1% to 100.0%, respectively. CONCLUSIONS: Ganglion cell-inner plexiform layer thickness shows significant interocular symmetry in normal subjects. An absolute interocular difference exceeding normal limits may be indicative of glaucoma.
Department of Ophthalmology, Seoul National University Hospital, Seoul, South Korea; Department of Ophthalmology, Seoul National University College of Medicine, Seoul, South Korea.
Full articleClassification:
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
