Abstract #92232 Published in IGR 22-1

Automated Direct Selective Laser Trabeculoplasty: First Prospective Clinical Trial

Goldenfeld M; Belkin M; Dobkin-Bekman M; Sacks Z; Blum Meirovitch S; Geffen N; Leshno A; Skaat A
Translational vision science & technology 2021; 10: 5

See also comment(s) by Tony Realini

PURPOSE: Direct selective laser trabeculoplasty (DSLT) is a rapid, noncontact automated procedure performed directly through the limbus without gonioscopy. In this first nonrandomized clinical trial we assessed its safety and ability to reduce intraocular pressure (IOP). METHODS: Fifteen patients (15 eyes: 10 with open-angle glaucoma [OAG], 4 with ocular hypertension, and 1 with pseudoexfoliation glaucoma), naive or after medication washout, with an IOP ≥22 mm Hg, underwent DSLT by irradiation with 100 or 120 sequential noncontact 532-nm, Q-switched laser shots (0.8-1.4 mJ) automatically applied during 1.5 or 2.3 seconds on the limbus, guided by image analysis and eye tracking. Results were assessed at 1 and 3 hours, 1 day, 1 week, and 1, 3, and 6 months. RESULTS: The mean ± standard deviation baseline IOP (mm Hg) in all eyes was 26.7 ± 2.3. At 1, 3, and 6 months, this value was significantly reduced to 21.7 ± 4.2 (by 18.1%), to 20.8 ± 2.5 (by 21.4%), and to 21.5 ± 4.1 (by 18.8%), respectively. In six patients treated with 1.4 mJ/shot, the mean IOP at 6 months decreased from 26.7 ± 3.2 to 19.3 ± 2.0 (27.1%, P = 0.03). There was a significant reduction in hypotensive medications (from 1.6 ± 1.0 to 0.4 ± 0.7, P = 0.03). No serious adverse events occurred. CONCLUSIONS: Automated DSLT appears to be an effective and safe noncontact, rapid modality for reducing IOP in patients with OAG. Higher energy usage led to better results. TRANSLATIONAL RELEVANCE: Studying laser transmission through sclera enabled laser irradiation of the trabeculum without gonioscopy.

The Sam Rothberg Glaucoma Centre, Goldschleger Eye Institute, Sheba Medical Centre, Tel Hashomer, Israel.

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12.4 Laser trabeculoplasty and other laser treatment of the angle (Part of: 12 Surgical treatment)

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