News Flashes IGR 20-4

The pandemic has created the opportunity for our specialty to advance new and innovative methods of health care delivery and accelerate research into making glaucoma care safer, more convenient, and more accessible to our patients than ever before

If remote perimetry/tonometry are ever going to become viable alternatives to in-clinic testing, now would be the time

Performing in vivo TM imaging with segmental information (such as from aqueous angiography) could yield additional insight into TM biology and potentially lead to novel outflow-based glaucoma therapies

The severity of glaucomatous optic nerve damage was not related with the degree of OSA

Slowing of glaucoma progression after IOP lowering treatment may be, at least partly, attributed, to the improved perfusion to the optic nerve

A more pronounced IOP reduction may be required in eyes with LC defects, because these eyes may be more susceptible to glaucoma progression

SLT is unlikely to have adequate treatment effect in patients requiring very low intraocular pressures

Phacoemulsification alone is able to decrease the IOP, reduce the extent of PAS and increase aqueous outflow facility

Optimal time for phacoemulsification to reduce the risk of trabeculectomy failure has been controversial

Cataract surgery within one year after trabeculectomy dramatically affect the success rate and should be avoided unless it is necessary

With the outcomes from LiGHT continuing to demonstrate the favorability of SLT, we are due an evidence-based paradigm shift

Lower parapapillary choroidal vessel density (VD) with B-zone parapapillary atrophy (PPA) at baseline is associated with future visual field progression

Advise against performing bench press to muscular failure with heavy loads in patients with glaucoma or risk factors

Isometric training with heavy loads (triggering Valsalva) is associated with IOP increase

Corneal deflection amplitude is an interesting corneal behavior that may be related to glaucoma progression

A possible beneficial effect on IOP in older adults which could protect against glaucoma

This device and study represent an important step toward the holy grail of accurate and continuous IOP monitoring in eyes with glaucoma

Bleb grading systems are fraught with error by nature of their subjectivity

This study shows that DL can also be used to directly model structure-function relationships and identify eyes with likely functional loss from OCT imaging

Examining features of imaging, other than thickness, e.g., texture or voxel intensity, may provide additional value for glaucoma detection and monitoring

Prior to the landmark Zhongshan Angle Closure Prevention (ZAP) trial, the benefit of treating PACS eyes with LPI was unclear

Authors estimated that 44 and 126 LPI would need to be performed to prevent one case of PAC and PACG, respectively

The LiGHT trial supports the use of a second SLT when an initial SLT is not enough to reach the target IOP or when the IOP further goes up

GRS-based genetic risk estimates may aid in early disease detection, thereby allowing for timely initiation of preventive treatment and management strategies

This paper demonstrates the molecular complexity of glaucoma and questions this division in glaucoma based on arbitrary measurements of intraocular pressure (IOP)

One can now safely say MYOC is no longer only a gene associated with only high IOP

The optical clarity presents an advantage over a number of murine mode, making this work a significant contribution to pre-clinical glaucoma modelling

Differing patient characteristics may have directed the surgeon toward insertion of the tube into the AC or PP, and this is a potential source of selection bias

The work is not yet able to conclude whether a specific strain pattern for any given ethnicity would be responsible for the development and progression and glaucoma

In-vivo ONH strains are thus more representative of what ONH cells directly experience

Moving forward, it is becoming clearer that glaucoma subjects would benefit from a clinical test to assess the robustness of their ONHs

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