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(1)

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Abstract #10495 Published in IGR 6-1

Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension

Rejdak R; Kohler K; Kocki T; Shenk Y; Turski WA; Okuno E; Lehaci C; Zagorski Z; Zrenner E; Schuettauf F
Vision Research 2004; 44: 655-660

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The study examines age-dependent changes of kynurenic acid (KYNA) content and kynurenine aminotransferases (KAT I and KAT II) celluar expression in the retinas of DBA/2J mice. Retinas were obtained from DBA/2J mice of different ages (three, six and 11 months). C57BL6 mice were used as controls. As measured with HPLC, KYNA content decreased (p < 0.01) in the retinas of 6-month-old DBA/2J mice and continued to decrease (p < 0.0074) in the retinas of 11-month-old animals compared to the controls. Immunohistochemistry showed that expression of both KAT I and KAT II decreased markedly in the retinas of 11-month-old DBA/2J mice compared to controls. The impairment in KYNA biosynthesis in the retinas of DBA/2J mice may be one of the mechanisms of retinal neurodegeneration related to ocular hypertension.

Dr. R. Rejdak, Department of Pathophysiology of Vision and Neuro-Ophthalmology, Division of Experimental Opthalmology, University Eye Hospital, Rontgenweg 11, 72076 Tubingen, Germany. rrejdak@yahoo.com

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Classification:

5 Experimental glaucoma; animal models
3.3 Immunohistochemistry (Part of: 3 Laboratory methods)

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