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Abstract #117041 Published in IGR 24-4
Revamping the corneal permeability and antiglaucoma therapeutic potential of brinzolamide using transniosomes: optimization, and preclinical evaluation
Patil RK; Srivastava V; Bhawale R; Tryphena KP; Khatri DK; Doijad N; Mehra NKNanomedicine 2024; 19: 947-964
This study aims to explore potential of transniosomes, a hybrid vesicular system, as ocular drug-delivery vehicle. Thin-film hydration technique was used to fabricate brinzolamide-loaded transniosomes (BRZ-TN) and optimized using Box-Behnken design, further exhaustively characterized for physicochemical evaluations, deformability, drug release, permeation and preclinical evaluations for antiglaucoma activity. The BRZ-TN showed ultradeformability (deformability index: 5.71), exhibiting sustained drug release without irritation (irritancy score: 0) and high permeability compared with the marketed formulation or free drug suspension. The extensive investigations affirmed effective targeted delivery of transniosomes, with brinzolamide reducing intraocular pressure potentially. Our findings anticipated that BRZ-TN is a promising therapeutic nanocarrier for effectively delivering cargo to targeted sites by crossing corneal barriers.
Pharmaceutical Nanotechnology Research Laboratory, Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, Telangana, 500037, India.
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