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Abstract #12135 Published in IGR 7-1
May glutathione S-transferase M1 positive genotype afford protection against primary open-angle glaucoma?
Yildirim O; Ates NA; Tamer L; Oz O; Yilmaz A; Atik U; Camdeviren HGraefe's Archive for Clinical and Experimental Ophthalmology 2005; 243: 327-333
PURPOSE: To find out whether the polymorphism at GSTM1, GSTT1 and GSTP1 loci is associated with increased susceptibility to glaucoma. METHODS: We genotyped 153 primary open angle patients and 159 healthy controls. Genomic DNA from peripheral blood was examined using polymerase chain reaction and defined for the genetic polymorphisms of glutathione S-transferase. RESULTS: The frequency of the GSTM1 null genotype individuals among the glaucoma patients was significantly higher than in controls (54.9 vs 40.9%) with odds ratio of 1.64 (95% CI: 1.10-2.59). The frequency of the GSTT1 and GSTP1 in both groups were not statistically different. CONCLUSION: The present study suggests that the GSTM1 null genotype may be a genetic risk factor for development of primary open angle glaucoma. Further associations studies in other polymorphic genes for xenobiotic-metabolizing enzymes are needed to elucidate the environmental-genetic interaction in the underlying cause of primary open angle glaucoma.
Dr. O. Yildirim, Department of Ophthalmology, Mersin Universitesi Tip Fakultesi, Mersin, Turkey. dryildirimoz@hotmail.com
Classification:
11.8 Neuroprotection (Part of: 11 Medical treatment)
