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Abstract #26710 Published in IGR 12-3
Reproducibility of OCT in children with glaucoma
El-Dairi MA; Noval S; Hornbeak DM; Holgado S; Asrani S; Freedman SFJournal of AAPOS 2010; 14: 16
Introduction: Optical Coherence Tomography(OCT) has been proven to be a useful clinical tool in the follow-up of adult glaucoma( IOVS2008;49:4886-4892.). Its use in pediatric glaucoma is limited because reproducibility has been assessed only in normal children and on the same visit (AJO,2007;143:484-488). This study's purpose is to evaluate the reproducibility of OCT in children with stable glaucoma in a clinical setting. Methods: OCT is used as part of standard care for childhood glaucoma patients treated at XXX pediatric ophthalmology clinic. Subjects with stable disease and who could perform OCT were enrolled prospectively and OCT-3 measures of both the Fast Macular Thickness and the Fast Retinal Nerve Fiber Layer (RNFL) 3.4 Thickness protocols were collected annually. Reproducility measures were assessed on subjects with >3 sequential scans. Results: Eighteen subjects with childhood glaucoma had 3-5 reliable fast macular thickness scans (age at enrollment, 4-16 years; mean, 9.5 (plus or minus) SD 3.1). Mean macular volume was 6.8 (plus or minus) 0.55 mm(3). Intraclass correlation coefficient was 95.8% with intervisit error of 0.1 mm(3). Six subjects had 3 reliable fast RNFL scans (mean age 10.2 (plus or minus) 2.8 (6-13) years). Mean RNFL thickness was 90.92 (plus or minus) 39.51. Intraclass correlation coefficient 90.9% with intervisit error of 13.4 mm. None of the subjects enrolled had a consistent trend towards RNFL or macular thinning or thickening. Conclusions: OCT has an acceptable reproducibility rate for clinical monitoring of children with glaucoma. Macular scans are easier to obtain and are more reproducible than RNFL scans. Further study comparing variability between normal children and those with glaucoma is underway.
M.A. El-Dairi.
Classification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
9.1.2 Juvenile glaucoma (Part of: 9 Clinical forms of glaucomas > 9.1 Developmental glaucomas)