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Abstract #47942 Published in IGR 13-4
Clinicopathologic correlations of poly-(styrene-b-isobutylene-b-styrene) glaucoma drainage devices of different internal diameters in rabbits
Arrieta EA; Aly M; Parrish R; Dubovy S; Pinchuk L; Kato Y; Fantes F; Parel J-MOphthalmic Surgery Lasers and Imaging 2011; 42: 338-345
(black square) BACKGROUND AND OBJECTIVE: To assess the biocompatibility and intraocular pressure (IOP) lowering effect of a novel glaucoma drainage implant in rabbits. (black square) MATERIALS AND METHODS: Sixteen New Zealand white rabbits received one of three glaucoma drainage implants fabricated from poly-(styrene-b-isobutylene-b-styrene [SIBS]) with an internal diameter of the lumen of either 70 (6 eyes), 100 (6 eyes), or 150 (4 eyes) (mu)m. Clinical follow-up examinations were performed during 6 months and postmortem eyes were studied with light microscopy. (black square) RESULTS: Smaller internal diameter implantswere associated with fewer complications. IOP levels were not statistically different among the groups. No eyes developed serious complications. Mild chronic inflammation was observed around the tube using light microscopy. (black square) CONCLUSION: SIBS glaucoma drainage implants did not produce clinically detectable intraocular inflammation in a rabbit model. The 70- and 100-(mu)m SIBS drainage devices demonstrated fewer postoperative complications. IOP levels were not statistically different from control eyes in all groups. Copyright (copyright) SLACK Incorporated.
E.A. Arrieta. Ophthalmic Biophysics Center, University of Miami, Miller School of Medicine, 1638 NW 10th Avenue, Miami, FL 33136, United States. Email: earrieta@med.miami.edu
Classification:
12.8.2 With tube implant or other drainage devices (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
