advertisement

Topcon

Abstract #51296 Published in IGR 14-3

Markers of Fas-mediated apoptosis in primary open-angle glaucoma and opportunities of their pharmacological correction

Slepova OS; Frolov MA; Morozova NS; Frolov AM; Lovpache DN
Vestnik Oftalmologii 2012; 128: 27-31


In order to assess the role of apoptosis in pathogenesis of primary open-angle glaucoma (POAG) apoptosis markers were studied in blood serum and tear fluid of patients with or suspected to have different stages glaucoma. To date the study of POAC pathogenesis goes along with search of possible ways of pharmacotherapy, neuroprotection is considered to be a promising option. Dynamics of sFas/Apo-1 and sFasL as the markers of Fas-mediated apoptosis was studied during treatment. We used nootropic citicoline as a neuroprotector. The markers were studied using enzyme immunoassay. The results show association of POAG onset and progression with interruption of Fas-mediated apoptosis, indicated by the level and proportion of sFas/Apo-1 and sFasL in tear fluid and in a less degree in blood serum. Characteristic features are detected in Fas/FasL system associated with glaucoma stage and correlating with some clinical and functional parameters (perimetry) that is important for understanding of POAG pathogenesis and for prognosis of disease course.


Classification:

11.8 Neuroprotection (Part of: 11 Medical treatment)



Issue 14-3

Change Issue


advertisement

Oculus