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Abstract #75294 Published in IGR 19-2
Pattern Electroretinography and Visual Evoked Potentials Provide Clinical Evidence of CNS Modulation of High- and Low-Contrast VEP Latency in Glaucoma
Sponsel WE; Johnson SL; Trevino R; Gonzalez A; Groth SL; Majcher C; Fulton DC; Reilly MATranslational vision science & technology 2017; 6: 6
PURPOSE: Both pattern electroretinography (PERG) and visual evoked potentials (VEP) can be performed using low- (15%; Lc) and high- (85%; Hc) contrast gratings that may preferentially stimulate the magno- and parvocellular pathways. We observed that among glaucomatous patients showing only one VEP latency deficit per eye, there appeared to be a very strong tendency for an Hc delay in one eye and an Lc delay in the other. METHODS: Diopsys NOVA-LX system was used to measure VEP Hc and Lc latency among a clinical glaucoma population to find all individuals with either a single Hc or Lc latency abnormality in each eye (group 1), or with greater than 0 and less than 4 Hc or Lc VEP latency abnormalities in the two eyes (group 2) to determine whether a significant inverse correlation existed for these values in either group. Hc and Lc PERG data were also evaluated to assess associated retinal ganglion cell responses. RESULTS: A strong inverse correlation ( = 0.0000003) was observed between the Hc and Lc VEP latency values among the 64 eyes in group 1. Group 2 provided a comparable result ( = 143; 286 eyes; = 0.0005). PERG ( = 81; 162 eyes) also showed strong bilateral symmetry for magnitude values ( < 0.0001 for both Lc and Hc in groups 1 and 2). CONCLUSIONS: Bilateral retention of both low-resolution/high-speed and high-resolution/low-speed function may persist with both eyes open despite symmetrically pathologic retinal ganglion cell PERG waveform asynchrony for Hc and Lc stimuli in the paired eyes. TRANSLATIONAL RELEVANCE: Clinical electrophysiology strongly suggests binocular compensation for dynamic dysfunction operates under central nervous system (CNS) control in glaucoma.
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Classification:
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)
