Abstract #82386 Published in IGR 20-4

Peripapillary Choroidal Vascularity Index and Microstructure of Parapapillary Atrophy

Suh MH; Park JW; Khandelwal N; Agrawal R
Investigative Ophthalmology and Visual Science 2019; 60: 3768-3775

PURPOSE: To investigate the association between the microstructure of β-zone parapapillary atrophy (βPPA) and choroidal vascularity index (CVI) determined by spectral-domain optical coherence tomography (SD-OCT) in glaucomatous eyes. METHODS: A total of 160 eyes of 160 primary open-angle glaucoma patients with βPPA were included. Total choroidal area (TCA), luminal area (LA), and CVI were measured at a 3.5-mm distance from the Bruch's membrane (BM) opening center by image binarization of SD-OCT B-scans. The widths of βPPA with BM (βPPA+BM) and without BM (βPPA-BM), and juxtapapillary choroidal thickness (JPCT) were measured on six radial SD-OCT images. OCT angiography-derived parapapillary deep-layer microvasculature dropout (MvD_P) was also derived. RESULTS: In the multivariate regression analysis, larger βPPA+BM was significantly associated with smaller TCA and smaller LA (P < 0.05, respectively), but not with CVI and JPCT (P > 0.05, respectively). Meanwhile, βPPA-BM was not significantly associated with TCA, LA, CVI, or JPCT in the multivariate regression analysis (P > 0.05). CONCLUSIONS: Despite significant relationship between the choroidal thinning and larger βPPA+BM, choroidal vascularity was not associated with the βPPA+BM width. These findings suggest that the presumed common pathogenic mechanism between RPE atrophy and peripapillary choroidal thinning may not be mediated by the impaired choroidal perfusion in glaucomatous eyes. Future studies on the mechanisms in explaining the relationship between the atrophy of retinal pigment epithelium (RPE) and choroid in glaucoma are needed.

Department of Ophthalmology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.

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2.12 Choroid, peripapillary choroid, peripapillary atrophy (Part of: 2 Anatomical structures in glaucoma)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods) Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)

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