Abstract #82835 Published in IGR 20-4

Acute Stress Increases Intraocular Pressure in Nonhuman Primates

Turner DC; Miranda M; Morris JS; Girkin CA; Downs JC
Ophthalmology. Glaucoma 2019; 2: 210-214

PURPOSE: To quantify intraocular pressure (IOP) change and time course during stressful activity. STUDY DESIGN: Experimental Study. SUBJECTS: Three nonhuman primates (NHPs). METHODS: Bilateral IOP and aortic blood pressure (BP) were recorded continuously, then averaged for periods of 8-30 seconds before, during, and after a common anesthetic induction procedure (cage squeeze followed by intramuscular injection). Experiments were repeated four times in each NHP. MAIN OUTCOME MEASURES: IOP, BP, and heart rate (HR) change during an anesthetic induction procedure. RESULTS: IOP, mean arterial pressure (MAP), and HR increased rapidly and significantly by 27%, 38%, 34%, respectively, in anticipation of anesthetic induction (Figure; <0.05). IOP rose ~10% within 10 seconds of hearing the technician enter the outer anteroom door, and reached its maximum within ~1 minute of first anticipating human contact. IOP fell to below baseline levels within 1 minute after anesthetic induction. CONCLUSIONS: IOP increases rapidly and significantly in response to stressful situations in the nonhuman primate.

Department of Vision Sciences, School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, USA.

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6.1.3 Factors affecting IOP (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
5.2 Primates (Part of: 5 Experimental glaucoma; animal models)

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