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WGW-2021

Abstract #82835 Published in IGR 20-4

Acute Stress Increases Intraocular Pressure in Nonhuman Primates

Turner DC; Miranda M; Morris JS; Girkin CA; Downs JC
Ophthalmology. Glaucoma 2019; 2: 210-214


PURPOSE: To quantify intraocular pressure (IOP) change and time course during stressful activity. STUDY DESIGN: Experimental Study. SUBJECTS: Three nonhuman primates (NHPs). METHODS: Bilateral IOP and aortic blood pressure (BP) were recorded continuously, then averaged for periods of 8-30 seconds before, during, and after a common anesthetic induction procedure (cage squeeze followed by intramuscular injection). Experiments were repeated four times in each NHP. MAIN OUTCOME MEASURES: IOP, BP, and heart rate (HR) change during an anesthetic induction procedure. RESULTS: IOP, mean arterial pressure (MAP), and HR increased rapidly and significantly by 27%, 38%, 34%, respectively, in anticipation of anesthetic induction (Figure; <0.05). IOP rose ~10% within 10 seconds of hearing the technician enter the outer anteroom door, and reached its maximum within ~1 minute of first anticipating human contact. IOP fell to below baseline levels within 1 minute after anesthetic induction. CONCLUSIONS: IOP increases rapidly and significantly in response to stressful situations in the nonhuman primate.

Department of Vision Sciences, School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Full article

Classification:

6.1.3 Factors affecting IOP (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
5.2 Primates (Part of: 5 Experimental glaucoma; animal models)



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WGC-2021