advertisement
Abstract #104961 Published in IGR 23-2
Patterns of Optical Coherence Tomography Imaging in Preperimetric Open-Angle Glaucoma: A Comparative Study with Young- and Old-Age-Onset Eyes
Bak E; Bak E; Bak E; Bak E; Sun S; Wy S; Kim YW; Kim YK; Park KH; Kim HC; Jeoung JWJournal of Glaucoma 2022; 31: 860-867
PRCIS: Optic coherence tomography imaging in preperimetric open-angle glaucoma differed between young- and old-age-onset eyes. Understanding the specific patterns of early-glaucomatous damage based on age-at-onset may improve glaucoma diagnosis and monitoring. PURPOSE: To investigate the patterns of retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thinning in preperimetric open-angle glaucoma (OAG) by optical coherence tomography (OCT) based on age at onset ("young-age onset (<40 y)" vs. "old-age onset (≥40 y)". MATERIALS AND METHODS: The RNFL and GCIPL deviation images were acquired by Cirrus HD-OCT, and overlaid, thus converted to a "deviation frequency map", respectively. The topographic thinning patterns and parameters of RNFL and GCIPL thickness measurements were compared. RESULTS: A total of 194 eyes of 194 patients with preperimetric OAG and 97 eyes of 97 age-matched normal subjects were analyzed. Young-age-onset eyes of preperimetric OAG mainly had RNFL defects inferotemporally (264-296°) with GCIPL defects in the inferior region (213-357°). Old-age-onset preperimetric OAG eyes had RNFL defects inferotemporally (266-294°) and superotemporally (33-67°), with GCIPL defects in the inferior and superior regions (206-360°, 0-22°). The inferior quadrant of RNFL and GCIPL thicknesses were significantly thinner in young-age-onset eyes compared with old-age-onset eyes (P=0.012, 0.016), while the superior quadrant of those were significantly thinner in the old-age-onset eyes (P=0.003, 0.005). CONCLUSION: Young- and old-age-onset eyes of preperimetric OAG present different specific patterns of RNFL and GCIPL thinning.
Full article
