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Abstract #25496 Published in IGR 12-1
The histopathological and immunohistochemical characteristics of pigmentary and cystic glaucoma in the Golden Retriever
Esson D; Armour M; Mundy P; Schobert C S; Dubielzig R RVeterinary Ophthalmology 2009; 12: 361-368
A clinical syndrome comprising the formation of thin-walled cysts within the posterior chamber, proteinaceous exudation, and pigment dispersion, which typically culminates in glaucoma is recognized in the Golden Retriever breed. Although not uncommon, this syndrome has been relatively infrequently documented in the literature, particularly from a histological standpoint. Fifteen globes from Golden Retrievers presented to Eye Care for Animals between 2003 and 2009 were evaluated by routine hematoxylin and eosin (H&E) as well as immunohistochemical staining. Alcian blue, periodic acid Schiff (PAS), Masson's trichrome, Cytokeratin, Vimentin, Neuron Specific Enolase (NSE), S-100, and smooth muscle actin staining were performed. The thin-walled cysts stained positive with Vimentin, NSE, and S-100 in 15/15 globes, consistent with a ciliary body epithelial cellular origin. No globes demonstrated goniodysgenesis. All 15 globes exhibited free pigment within the trabecular meshwork. Little to no inflammatory infiltrate was noted in 15/15 eyes. These findings suggest that the term 'uveitis' may be an inappropriate description of this syndrome.
D. Esson. Eye Care for Animals, 3025 Edinger Ave, Tustin, CA 92780, United States. desson@eyecareforanimals.com
Classification:
9.4.3.1 Pigmentary glaucoma (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.3 Glaucomas associated with disorders of the iris and ciliary body)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
3.3 Immunohistochemistry (Part of: 3 Laboratory methods)