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Abstract #8459 Published in IGR 5-1
Case control study on the risk factors of primary open angle glaucoma in China
Wang N; Peng Z; Fan B; Liu Y; Dong X; Liang X; Luan JZhonghua Liu Xing Bing Xue Za Zhi 2002; 23: 293-296
OBJECTIVE: The purpose of this study was to comprehensively explore the risk factors of primary open-angle glaucoma (POAG) in China. METHODS: Two groups of data based on distinct resources were analyzed to explore the risk factors of POAG. One group of data was based on hospital records between 1995 and 2000, and was comprised of 107 patients with POAG and 149 controls without POAG. The other group of data was based on 40 patients with POAG and 120 matched controls without POAG. The former was a non-matched case control study, the latter a 1:3 matched case control study. The relationships between POAG and factors such as age, sex, family history, diabetes, hypertension, intraocular pressure (IOP), cardiovascular diseases, smoking, drinking, and mutation of TIGR gene were studied by logistic regression analysis. RESULTS: Simple factor analysis showed that the risk of POAG was related to age, family history, hypertension, IOP, cardiovascular diseases, smoking, drinking, and the mutation of TIGR gene (T353I). However, logistic regression analysis confirmed that POAG was mainly related to IOP, family history, hypertension, smoking, alcohol intake, and the mutation of TIGR gene. CONCLUSIONS: The most important risk factor for POAG was IOP. Family history, hypertension, smoking, and the mutation of TIGR gene were also important risk factors for POAG. However, alcohol intake was a protective factor for POAG.LA: Chinese
Dr. N. Wang, Department of Epidemiology & Biostatistics, School of Public Health, Southeast University, Nanjing 210009, China
Classification:
9.2.1 Ocular hypertension (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
