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Abstract #8762 Published in IGR 5-1
Evaluation analysis of blood flow of peripapillary area in glaucoma patients using scanning laser Doppler flowmetry
Nizankowska MH; Jamrozy-Witkowska A; Asejczyk MKlinika Oczna 2002; 104: 201-206
PURPOSE: To evaluate capillary blood flow and velocity in retinal peripapillary area in primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), pseudoexfoliation glaucoma (PEXG) and an age-matched control group (C) using scanning laser Doppler flowmetry (Heildelberg Retina Flowmeter). MATERIAL AND METHODS: One randomly selected eye of 17 POAG patients (mean age, 59.3 ± 2.6 years), 18 NTG patients (mean age, 56.4 ± 2.4 years), 17 PEXG patients (63.3 ± 2.8 years), and 15 healthy subjects (mean age, 55.8 ± 3.8 years) underwent examination with scanning laser Doppler flowmetry. The measurements were performed at the superior and inferior temporal peripapillary retinal area. The parameters measured were capillary blood flow and velocity of the moving erythrocytes. Each image was analyzed using the program AFFPIA. This software calculates the hemodynamic parameter flow of each pixel. Comparison of value obtained from patients and control participants were made using Student's t test. RESULTS: Scanning laser Doppler flowmetry results showed a significant reduction in blood flow at the superior and inferior temporal peripapillary area in POAG and NTG patients compared to the control group (p < 0.04). POAG and NTG patients also had significantly decreased velocity at the inferior temporal peripapillary retinal area compared to the control group. No statistical difference was found between blood flow and velocity in POAG compared to NTG patients. When compared with controls, patients with PEXG showed significant decreases in mean blood flow at the inferior temporal quadrant (p < 0.05), while the differences in mean flow and velocity at the superior quadrant between those groups were not statistically significant. CONCLUSIONS: These findings indicate a reduction in ocular blood flow at the temporal peripapillary retinal area in patients with POAG and NTG compared to age-matched controls. The peripapillary retinal microcirculation is not significantly altered in patients with PEXG compared to POAG and JNC. Blood flow parameters in the capillaries are lower in JNC retinas, however, the difference is not significant. Further clinical investigation is required in homogeneous groups with respect to stage of glaucoma, and controlled for factors known to effect perfusion pressure.LA: Polish
Dr. M.H. Nizankowska, Katedry i Kliniki Okulistyki Akademii Medycznej we Wroclawiu, Poland
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
