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Abstract #8781 Published in IGR 5-1
The endothelin-1 level in blood serum of patients with primary open angle glaucoma and its influence on the static perimetry and GDx changes
Pienkowska-Machoy E; Millo BKlinika Oczna 2002; 104: 214-217
PURPOSE: The aim of this work was to define the relationships between the endothelin-1 (ET-1) level in the blood serum of glaucoma patients with regard to visual field defects and number of nerve fibers. MATERIAL AND METHODS: Twenty-four females and 14 males, aged 38-74 years (mean, 53.4 years) with primary open-angle glaucoma (POAG), without any systemic diseases. The control group consisted of 20 healthy males and females, aged 34-70 years (mean, 52.6 years). ET-1 levels were tested in the blood serum using the enzymo-immunological method. Visual field defects were examined using Humphrey static perimetry. Nerve fibers were analyzed with the GDx apparatus. RESULTS: Mean values of ET-1 in the blood serum were similar in both examined groups: 0.51 in the glaucoma group and 0.54 (fmol/l) in the control group. There were no significant correlations between ET-1 level, static perimetry, GDx parameters, and age in the glaucoma group. Statistical significance was given for ET-1 level and MD parameter in static perimetry (p < 0.03) and ET-1 level with the Number: the GDx parameter (p < 0.03). CONCLUSIONS: There was no significant level of ET-1 in blood serum in group of patients with POAG. No relationship was seen between static perimetry and GDx changes in patients with POAG and ET-1 level in the blood serum. This is a preliminary communication.LA: Polish
Dr. E. Pienkowska-Machov, Katedry Okulistyki z Klinika i Zakladem Patofizjologii Narzadu Wzroku, Poland
Classification:
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
