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Abstract #8372 Published in IGR 5-1
Modification of ocular defects in mouse developmental glaucoma models by tyrosinase
Libby RT; Smith RS; Savinova OV; Zabaleta A; Martin JE; Gonzalez FJ; John SWScience 2003; 299: 1578-1581
Mutations in the cytochrome P450 family 1, subfamily B, polypeptide 1 (CYP1B1) gene are a common cause of human primary congenital glaucoma (PCG). Here the authors show that Cyp1b1-/- mice have ocular drainage structure abnormalities resembling those reported in human PCG patients. Using Cyp1b1-/- mice, they identified the tyrosinase gene (Tyr) as a modifier of the drainage structure phenotype, with Tyr deficiency increasing the magnitude of dysgenesis. The severe dysgenesis in eyes lacking both CYP1B1 and TYR was alleviated by administration of the tyrosinase product dihydroxyphenylalanine (l-dopa). Tyr also modified the drainage structure dysgenesis in mice with a mutant Foxc1 gene, which is also involved in PCG. These experiments raise the possibility that a tyrosinase/l-dopa pathway modifies human PCG, which could open new therapeutic avenues.
Dr. R.T. Libby, Jackson Laboratory, Bar Harbor, ME 04609, USA
Classification:
1.2 Population genetics (Part of: 1 General aspects)
5 Experimental glaucoma; animal models
