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Abstract #8425 Published in IGR 5-1
Intraocular pressure fluctuations in medical versus surgically treated glaucomatous patients
Medeiros FA; Pinheiro A; Moura FC; Leal BC; Susanna R JrJournal of Ocular Pharmacology and Therapeutics 2002; 18: 489-498
The purpose of this study was to compare IOP fluctuations in the daytime tension curves of glaucoma patients under ocular hypotensive therapy with those of patients previously submitted to trabeculectomy. The authors also evaluated IOP peaks and fluctuations in the same patients in response to the water-drinking test (WDT). The study included 30 primary open-angle glaucoma (POAG) patients using ocular hypotensive medications and with no history of previous intraocular surgery (medical group), and 30 POAG patients previously submitted to one or more trabeculectomies although taking no medication at the time of the study (surgical group). All patients were underwent a diurnal tension curve (DTC; 8:30-17:00/three-hour intervals) followed by WDT. IOP peaks and fluctuations during DTC were significantly greater in the medical group than in the surgical group. The same was observed following WDT. From an overall baseline IOP of 10.6 mmHg, the mean IOP change following WDT was 13% in the surgical group and 40% in the medical group. Patients submitted to trabeculectomy have less IOP fluctuations during DTC and following a water-drinking provocative test. This effect could represent an additional benefit of surgery in controlling IOP in glaucomatous patients.
Dr. F.A. Medeiros, 5350 Toscana Way #E-111, San Diego, CA 92122, Brazil. fmedeiros@uol.com.br
Classification:
6.1 Intraocular pressure measurement; factors affecting IOP (Part of: 6 Clinical examination methods)
11.1 General management, indication (Part of: 11 Medical treatment)
11.2 Cholinergic drugs (Part of: 11 Medical treatment)
