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Abstract #8462 Published in IGR 5-1
Homocysteine and risk of open-angle glaucoma
Bleich S; Junemann A; von Ahsen N; Lausen B; Ritter K; Beck G; Naumann GOH; Kornhuber JJournal of Neural Transmission 2002; 109: 1499-1504
Homocysteine levels and the frequency of heterozygous methylenetetrahydrofolate reductase (MTHFR) C677T mutation are increased in open-angle glaucoma. Since homocysteine can induce vascular injury, alterations in extracellular matrix remodelling, and neuronal cell death, these findings may have important implications for understanding glaucomatous optic neuropathy.
Dr. S. Bleich, F.-A. University of Erlangen-Nuremberg, Department of Psychiatry, Schwabachanlage 6-10, D-91054 Erlangen, Germany. stefan.bleich@psych.imed.uni-erlangen.de
Classification:
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
