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Abstract #8533 Published in IGR 5-1
Drop volume, rigidity and required squeezing force of glaucoma ophthalmic solution containers
Yoshikawa K; Yamada HJapanese Journal of Clinical Ophthalmology 2002; 56: 1587-1593
The authors evaluated ten commercially-available glaucoma ophthalmic solutions regarding drop volume, rigidity and required squeezing force of containers. The drop volume ranged from 0.027-0.044 g. The rigidity of containers ranged from 8.2-17.1 N. The squeezing force ranged from 7.0-11.8 N. The drop volume was significantly correlated with neither the rigidity nor the squeezing force. They then made eye drop containers using three different materials, i.e., low-density polyethylene, polypropylene, and polyethylene terephthalate. The drop volume ranged from 0.045-0.049 g. The drop volume was significantly correlated neither with the rigidity or squeezing force of the containers. From these findings, it is concluded that the rigidity or squeezing force does not influence the drop volume from glaucoma ophthalmic solutions containers.LA: Japanese
Dr. K. Yoshikawa, Yoshikawa Eye Clinic, 1-3-1 Nakamachi, Machida-shi Tokyo,194-0021, Japan
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
