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Abstract #8575 Published in IGR 5-1
Comparison of latanoprost and dorzolamide in patients with open angle glaucoma
Ahmad Lone I; Rizvi A; Sajjad Ahmad S; Ahmad Unto RJK Science 2003; 5: 26-28
To compare the ocular hypotensive efficacy and side-effects of either latanoprost or dorzolamide in patients with open angle glaucoma, 44 patients with open angle glaucoma were included in a randomized, double masked study for a period of three months. All previous glaucoma medications were stopped and the patients were randomized to receiving either latanoprost 0.005% at bed time or dorzolamide 2% three times daily. After three months, the mean reduction in IOP was 6.8 (SD 3.1) Hg in the latanoprost group compared to 4.7 (SD 2.4) mmHg in the dorzolamide group. The difference of 2.1 mmHg was highly significant. Both the drugs were well tolerated systemically and locally. Latanoprost was superior to dorzolamide in reducing the mean intraocular pressure and thus has the potential for becoming the first line treatment in glaucoma.
Dr. I. Ahmad Lone, Department of Ophthalmology, SKIMS Medical College, Bemina, Srinagar-190011, India
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)
