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Abstract #8582 Published in IGR 5-1
Vasoactive properties of bimatoprost in isolated porcine ciliary arteries
Allemann R; Flammer J; Haefliger IOKlinische Monatsblätter für Augenheilkunde 2003; 161-164
BACKGROUND: To investigate the vasoactive effect of bimatoprost (Lumigan®), a new topical ocular hypotensive agent, in isolated porcine ciliary arteries. Material and METHODS: Arteries were placed in a myograph system to measure isometric forces. Quiescent vessels as well as vessels pre-contracted with either 10 nm endothelin-1 or 100 mm potassium chloride (KCl) were exposed, in a cumulative manner, to increasing concentrations (0.1 nm - 0.1 mm) of bimatoprost (dissolved in ethanol). In quiescent vessels, results were expressed in percent of 100 mm KCl-induced contraction. In endothelin-1-pre-contracted vessels, results were expressed in percentage of the maximal contraction induced by endothelin-1. In KCl-pre-contracted vessels, results were expressed in percentage of the plateau contraction reached 30 minutes after 100 mm KCl application. RESULTS: Bimatoprost induced a significant (p < 0.05-0.001) vasoconstriction at concentrations equal to or higher than 0.1 μm in quiescent vessels (0.1 mm: 73 ± 12%). In KCl-pre-contracted vessels, at concentrations higher than 1 μm, bimatoprost induced significant (p < 0.05-0.01) contractions (0.1 mm: 67 ± 17%). In endothelin-1-pre-contracted vessels, bimatoprost also induced significant (p < 0.05-0.001) contractions at concentrations above 10 μm (0.1 mm: 17 ±8 %). CONCLUSIONS: The present study indicates that bimatoprost appears to have, in vitro, some vasoactive properties in porcine ciliary arteries. The question of whether Lumigan® has an influence on ocular blood flow needs to be further investigated.
Dr. R. Allemann, Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Switzerland
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
