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Abstract #8606 Published in IGR 5-1
Blood pO2 and blood flow at the optic disc
Chamot SR; Cranstoun SD; Petrig BL; Pournaras CJ; Riva CEJournal of biomedical Optics 2003; 8: 63-69
A fundus camera-based phosphorometer to noninvasively and quasicontinuously measure the blood partial pressure of oxygen (pO2,blood) in the microvasculature of the porcine optic nerve using the principle of the phosphorescence quenching by O2 is described. A porphyrin dye is injected into the venous circulation and the decay of its phosphorescence emission is detected locally in the eye, after excitation with a flash of light. Combined with blood flow measurements by means of a laser Doppler flowmeter mounted on the phosphorometer, the capability of the instrument to determine the time course of optic nerve blood flow and pO2,blood is demonstrated in response to various physiological stimuli, such as hyperoxia and hypercapnia. This instrument appears to be a useful tool in the investigation of oxygenation of the optic nerve.
Dr. S.R. Chamot, Institut de Recherche en Ophtalmologie, Grand Champsec 64, CP 4168, 1950 Sion 4, Switzerland. stephane.chamot@iro.vsnet.ch
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
