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Abstract #8694 Published in IGR 5-1
Retinal nerve fiber layer analysis and evaluation of eye blood flow in patients with glaucoma
Karczewicz D; Modrzejewska M; Kuprjanowicz LKlinika Oczna 2002; 104: 207-210
PURPOSE: The aim of this research was to evaluate the changes of blood flow velocity in the ocular arteries (ophthalmic artery, central retinal artery and short posterior ciliary arteries) and the amount of ocular nerve fibers in patients with primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG). MATERIAL AND METHODS: The research was carried out in 17 patients with diagnosed POAG and 13 with NTG. No ocular surgery was performed on any of these patients prior to the examinations. Blood flow measurements were performed with ACUSON Color Doppler USG 128*P10 type with a 7.5 mHz sector phased probe. Parameters of diastolic velocity (Vr), systolic flow velocity (Vs), Golsing pulsation index (PI), and pourcelate resistivity index (RI) were registered, together with the instant spectrography of examined artery. Quantitative retinal nerve fiber layer (RNFL) measurements were obtained by scanning laser polarimetry GDx (software version 1.0.14). RNFL was measured automatically in each of 256x 256 pixels and results were compared with age-, sex- and race-norms. An approximately 150-wide field of view was used. Average thickness, Superior Maximum, Inferior Maximum, maximum modulation and GDx Number were analyzed. All results were compared to age norms. Student's t test was used for statistical analysis. RESULTS: In patients with POAG, a statistically significant decrease of Vs in the ophthalmic artery was detected in 27% of eyes, in the central retinal artery in 51% of eyes, and in the short posterior ciliary arteries in 45% of eyes. In patients with NTG, a statistically significant decrease of Vs was detected in the ophthalmic artery in 27% of eyes, in the central retinal artery in 65% of eyes, and in the short posterior ciliary arteries in 53% of eyes. RNFL analysis in eyes with POAG showed a decrease in average thickness in 80% of eyes, a decrease in Superior Maximum in 84% of eyes, a decrease in Inferior Maximum in 77.4% of eyes, a decrease in maximal modulation in 87% of eyes, and an increase in GDx Number in 77% of eyes. RNFL analysis in patients with NTG showed a decrease in average thickness in 73% of eyes, a decrease in Superior Maximum in 80.7% of eyes, a decrease in Inferior Maximum in 65.7% of eyes, a decrease in maximal modulation in 61.5% of eyes, and an increase of GDx Number in 57.6% of eyes.LA: Polish
Dr. D. Karczewicz, Katedry Okulistyki z Klinika i Zakladem Patofizjologii Narzadu Wzroku Pomorskiej Akademii Medycznej w Szczecinie, Poland
Classification:
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
6.9.1 Laser scanning (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)
