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Abstract #8727 Published in IGR 5-1
Hyperhomocystinemia in pseudoexfoliation glaucoma
Leibovitch I; Kurtz S; Shemesh G; Goldstein M; Sela BA; Lazar M; Loewenstein AJournal of Glaucoma 2003; 12: 36-39
PURPOSE: To determine the prevalence of hyperhomocystinemia in patients with pseudoexfoliation glaucoma. PATIENTS AND METHODS: This prospective study included 30 patients with glaucoma and 30 age-matched controls with no history of ocular disease who were undergoing routine physical checkups. Plasma homocysteine levels of all the study participants were determined using high-performance liquid chromatography, and values exceeding 15 μmol/L were considered elevated. RESULTS: The mean plasma homocysteine level was 16.80 ± 3.20 and 12.39 ± 1.97 μmol/L in glaucoma patients and controls, respectively (p < 0.0001). Fifteen glaucoma patients (50%) had hyperhomocystinemia compared with three controls (10%) (P = 0.0015). CONCLUSIONS: Hyperhomocystinemia may be associated with pseudoexfoliation glaucoma, which may partially explain the increased risk of vascular diseases among patients with pseudoexfoliation syndrome.
Dr. I. Leibovitch, Department of Ophthalmology, Tel-Aviv Sourasky Medical Center, Israel. lleibo@bezeqint.net
Classification:
9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
